Abstract: Materialists have advanced several arguments to show that “downward causation” (mental to physical causation) is impossible. It is claimed that downward causation: (1) violates the causal closure of the physical; (2) is incompatible with natural law; (3) cannot be reconciled with the empirical evidence from neuroscience. This paper responds to these objections by arguing that: (1) there is no good reason to believe that the physical is causally closed; (2) properly understood, natural laws are compatible with downward causation; (3) recent findings in neuroscience reported by Schwartz, Beauregard and others provide strong empirical support for downward causation.